The Spaniard's withdrawal means Medvedev will be top seed at the March 1-7 event, which also features top-10 players Stefanos Tsitsipas and Alexander Zverev.
Russian seventh seed Daniil Medvedev, the 2023 Miami champion who arrived this year fresh off a run to the Indian Wells semi-finals, crashed out at the first hurdle as he fell 6-2, 6-3 to Spaniard Jaume Munar.
Sinner advanced with a 6-3, 7-6 (3) victory over home favorite Bu Yunchaokete and No. 2 seed Alcaraz held off No. 3 Daniil Medvedev 7-5, 6-3 in Tuesday's semifinals.
IMAGES from Day 9 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Tuesday.
Daniil Medvedev quelled the challenge of wildcard Arthur Fery and Marta Kostyuk fought back to upset Maria Sakkari and storm into the Wimbledon second round on a rainy Wednesday.
Daniil Medvedev was fined for an outburst against the umpire
Images from the men's singles semi-finals at the US Open semi-finals, at Flushing Meadows, New York, on Friday.
Top seed Taylor Fritz of the United States was beaten by Spanish eighth seed Alejandro Davidovich Fokina in the quarter-finals.
It was billed as the battle of the 20-year-olds but Carlos Alcaraz pulled rank on his childhood buddy Holger Rune to enter the Wimbledon semifinals.
US Open champion Daniil Medvedev may have to provide assurances that he does not support Russian president Vladimir Putin if he is to compete at this year's Wimbledon, British Sports Minister Nigel Huddleston said on Tuesday.
Images from the US Open men's singles quarter-finals at Flushing Meadows, New York, on Wednesday.
Nick Kyrgios produced a serve-and-volley masterclass to topple world number one Daniil Medvedev 6-7(2), 6-4, 6-2 for his eighth straight win on a day of upsets, while American Tommy Paul rallied to beat Spanish second seed Carlos Alcaraz.
'Of course I am happy to reach No. 1. It was my goal since I was young and especially my goal in the latest times.'
Rather than face the prospect of a lengthy ban, with a decision expected by the end of the year, World No 1 Jannik Sinner accepted the three-month suspension which will allow him to return before the French Open.
Jannik Sinner beat defending champion and Spanish second seed Carlos Alcaraz to win his first Wimbledon title.
The Russian ended Djokovic's hopes of completing a sweep of all four Grand Slam titles in 2021 when he defeated the Serb in the US Open final in September to pick up his maiden major.
Second seed Coco Gauff overcame early problems on serve to cruise past China's Wang Xinyu 6-3, 6-2, keeping her composure despite eight double faults in the first set to book a meeting with Ukraine's Dayana Yastremska in the third round.
IMAGES from Day 10 of the US Open, at the USTA Billie Jean King National Tennis Center, Flushing Meadows, New York.
Athletes from Russia and Belarus, Moscow's closest ally in the 2022 invasion of Ukraine, are barred from the Paris Games except for the few who will compete as neutral athletes without flags or anthems.
A very different Australian Open comes to a familiar end on Sunday as Novak Djokovic looks to thwart another challenge to his Melbourne Park dynasty from the latest Grand Slam aspirant in Daniil Medvedev.
The 25-year-old Medvedev, who has played Grand Slam finals at the Australian and US Opens, is certainly expecting to go through to the second round at Roland Garros.
World number one Novak Djokovic's French Open preparations were dealt with a blow as he suffered a 6-3, 4-6, 6-2 defeat by Russian Daniil Medvedev in the Monte Carlo Masters quarter-finals on Friday.
The prize money pool for this year's U.S. Open has been increased by 15% to $75 million, making it the largest purse in tennis history, the United States Tennis Association announced on Wednesday.
Novak Djokovic won a record-extending sixth Paris Masters title by avenging his U.S Open final defeat against Russian Daniil Medvedev with a 4-6, 6-3, 6-3 victory in Sunday's showpiece match.
Zverev is also in fine form, having beaten world number one Novak Djokovic on his way to claiming the Olympic gold medal in Tokyo at the start of the month.
Alexander Zverev continued to rebuild his confidence on clay with a straight sets win over Spain's Roberto Bautista Agut in the Monte Carlo Masters second round.
Medvedev whips Dimitrov to enter US Open final
His top ranking came on the same day that Russia launched a full-scale invasion of Ukraine that began with air and missile strikes on military facilities before troops and tanks rolled across borders from the north, east and south.
Sparks flew when they met for the first time on the ATP Tour in Miami, with Medvedev confronting the Greek over his on-court conduct.
Novak Djokovic's outstanding serving, mighty forehand and all-court defence delivered him a ninth straight win over Stefanos Tsitsipas in their Red Group match.
Rafael Nadal beat new world number one Daniil Medvedev 6-3, 6-3 in a rematch of their Australian Open clash to storm into the final of the ATP 500 event in Acapulco on Friday.
'Can't leave grass,' the 26 year old captioned an image posted on his social media pages.
IMAGES from Day 6 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Saturday.
Alcaraz, whose tournament so far has been typified by lapses in concentration and drops in intensity, was on the back foot as Medvedev clinched the first set in a tiebreak.
Fourth seed Medvedev had won all his previous matches against Rublev in straight sets and it was no different at a scorching Rod Laver Arena on Wednesday.
Daniil Medvedev's bid to reclaim the world number one ranking fell short on Thursday as the Russian lost 7-6(7), 6-3 to Poland's Hubert Hurkacz in the Miami Open quarter-finals.
'I'm happy to have the chance to try to stop, one more time, somebody from making history.'
Daniil Medvedev was knocked out in the fourth round of Indian Wells by Bulgarian Grigor Dimitrov on Wednesday as the world number two's near-flawless start turned nightmarish in a 4-6, 6-4, 6-3 defeat.
Medvedev will be glad to play the role of dream wrecker once again.
'I have the feeling that people [are] starting more and more to... respect what he has done in tennis more and more, because he continues to beat the records'.
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